MetalloNeuroChemistry Lab (MNCL)

Research Overview    

The research interests of the Lim lab lie in the broad field of bioinorganic chemistry as it interfaces with chemical biology, biochemistry, medicinal chemistry, and neuroscience. Our research objectives are to (a) identify how metal-involved biological networks composed of proteins, neurotransmitters, and mediators for oxidative stress and inflammation are linked to dementia, including Alzheimer’s and Parkinson’s diseases (AD and PD); (b) establish new directions for developing chemical reagents as tools, diagnostics, and therapeutics for such diseases. These goals can be accomplished through (i) elucidating the complicated and inter-communicated pathogenesis of dementia at the molecular level; (ii) designing small molecule-based or protein-based reagents as chemical tools through understanding of the complicated networks among metals, various proteins, and/or other molecules (i.e., neurotransmitters), and as multi-tasking diagnostics or therapeutics. Students in the Lim lab have been engaging in synthetic chemistry (organic and inorganic syntheses), physical methods (NMR, EPR, IR, CD, and UV-vis spectroscopy, mass spectrometry, and X-ray crystallography), as well as biochemical and biological techniques (biochemical assays, mammalian cell culture/analysis, and in vivo investigations).   

Recent Publications     

7. Jiyeon Han, Hyuck Jin Lee, Kyu Yeon Kim,Shin Jung C. Lee, Jaeheung Cho, Junghyun Chae,* Mi Hee Lim* ACS Chem. Neurosci. 2018, Accepted for Publication. "Tuning Structures and Properties for Developing Novel Chemical Tools Towards Distinct Pathogenic Elements in Alzheimer's Disease" 
6. Taesu Choi, Hyuck Jin Lee, Jong Yoon Han, Mi Hee Lim,* Hugh I. Kim* J. Am. Chem. Soc. 2017, 139, 15437-15445. "Molecular Insights into Human Serum Albumin as a Receptor of Amyloid-β in the Extracellular Region " 
5. Michael W. Beck, Jeffrey S. Derrick, Jong-Min Suh, Mingeun Kim, Kyle J. Korshavn, Richard A. Kerr, Woo Jong Cho, Scott D. Larsen, Brandon T. Ruotolo, Ayyalusamy Ramamoorthy,* Mi Hee Lim* ChemMedChem 2017, 12, 1828-1838. “Minor Structural Variations of Metal Chelators Tune Regulatory Activities towards Pathological Factors in Alzheimer’s Disease” 
4. Eunju Nam, Jiyeon Han, Jong-Min Suh, Yelim Yi, and Mi Hee Lim* Curr. Opin. Chem. Biol. 2018, 43, 8-11. "Link of Impaired Metal Ion Homeostasis to Mitochondrial Dysfunction in Neurons" 
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Recent News

90. December 2017: Congrats, Yonghwan, for his MS degree! Master Yonghwan! 
89. December 2017: Congrats, Professor Lim, Jeff, Shinjung, Eunju, Juhye, Misun, for their work (JACS 2017) being selected for "2017 국내 바이오분야 연구성과 및 뉴스 Top 5"  
88. December 2017: Congrats, Jiyeon, Hyuck Jin, and Jong-Min, for publishing their work in ACS Chem. Neurosci.! 
87. December 2017: Good Job, Geewoo, for finishing his qualified exam! PhD Candidate! 
86. December 2017: Congrats, Jiyeon, for her successful MS defense! 
85. November 2017: Congrats, Michael, Jeff, Mingeun, Jong-Min, for being featured as a Front Cover for their paper work in ChemMedChem! 
84. September 2017: Congrats, Hyuck Jin, for publishing his work in collaboration with the lab of Professor Hugh I. Kim in J. Am. Chem. Soc. 
83. September 2017: Congrats, Michael, Jeff, Jong-Min, and Mingeun, for publishing their work in ChemMedChem. 
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