MetalloNeuroChemistry Lab (MNCL)

Research Overview    

The research interests of the Lim lab lie in the broad field of bioinorganic chemistry as it interfaces with chemical biology, biochemistry, medicinal chemistry, and neuroscience. Our research objectives are to (a) identify how metal-involved biological networks composed of proteins, neurotransmitters, and mediators for oxidative stress and inflammation are linked to dementia, including Alzheimer’s and Parkinson’s diseases (AD and PD); (b) establish new directions for developing chemical reagents as tools, diagnostics, and therapeutics for such diseases. These goals can be accomplished through (i) elucidating the complicated and inter-communicated pathogenesis of dementia at the molecular level; (ii) designing small molecule-based or protein-based reagents as chemical tools through understanding of the complicated networks among metals, various proteins, and/or other molecules (i.e., neurotransmitters), and as multi-tasking diagnostics or therapeutics. Students in the Lim lab have been engaging in synthetic chemistry (organic and inorganic syntheses), physical methods (NMR, EPR, IR, CD, and UV-vis spectroscopy, mass spectrometry, and X-ray crystallography), as well as biochemical and biological techniques (biochemical assays, mammalian cell culture/analysis, and in vivo investigations).   

Recent Publications     

6. Taesu Choi, Hyuck Jin Lee, Jong Yoon Han, Mi Hee Lim,* Hugh I. Kim* J. Am. Chem. Soc. 2017, In Press. "Molecular Insights into Human Serum Albumin as a Receptor of Amyloid-b in the Extracellular Region " 
5. Michael W. Beck, Jeffrey S. Derrick, Jong-Min Suh, Mingeun Kim, Kyle J. Korshavn, Richard A. Kerr, Woo Jong Cho, Scott D. Larsen, Brandon T. Ruotolo, Ayyalusamy Ramamoorthy,* Mi Hee Lim* ChemMedChem 2017, In Press. “Minor Structural Variations of Metal Chelators Tune Regulatory Activities towards Pathological Factors in Alzheimer’s Disease” 
4. Eunju Nam, Jiyeon Han, Jong-Min Suh, Yelim Yi, and Mi Hee Lim* Curr. Opin. Chem. Biol. 2017, In Press. "Link of Impaired Metal Ion Homeostasis to Mitochondrial Dysfunction in Neurons" 
3. Jeffrey S. Derrick, Yujeong Kim, Hyeonwoo Tak, Kiyong Park,* Jaeheung Cho,* Sun Hee Kim,* Mi Hee Lim* Dalton Trans. 2017, In Press. "Stereochemistry of Metal Tetramethylcyclam Complexes Directed by an Unexpected Anion Effect" 
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Recent News

84. September 2017: Congrats, Hyuck Jin, for publishing his work in collaboration with the lab of Professor Hugh I. Kim in J. Am. Chem. Soc. 
83. September 2017: Congrats, Michael, Jeff, Jong-Min, and Mingeun, for publishing their work in ChemMedChem. 
82. September 2017: Congrats, Eunju, Jiyeon, Jong-Min, and Yelim, for publishing their summary in Curr. Opin. Chem. Biol. 
81. September 2017: Welcome, our new graduate student, Nahye! 
80. July 2017: Juhye and Jiyeon, Congrats for the Poster Awards in the 2017 Bioinorganic Symposium. 
79. July 2017: Our lab was highlighted by "화학세계" 
78. May 2017: Congrats, Jeff, for publishing his work in Dalton Trans. 
77. May 2017: Congrats, Yonghwan, Hyuck Jin, Geewoo, for publishing their work in Inorg. Chem.! 
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