MetalloNeuroChemistry Lab (MNCL)

Research Overview    

The research interests of the Lim lab lie in the broad field of bioinorganic chemistry (chemical biology) as it interfaces with chemical biology, biochemistry, medicinal chemistry, and neuroscience. Our research objectives are to (a) identify the etiologies of human neurodegenerative disorders [particularly, elucidation of the roles of metals, proteins, and reactive oxygen species (ROS) individually or mutually in human neurodegenerative diseases]; (b) discover new, effective therapeutics for these diseases. These goals can be accomplished through designing small molecule-based or protein-based reagents (i) as chemical tools through understanding of the complicated networks between metals, various proteins and/or other molecules (i.e., neurotransmitters); (ii) as multi-tasking therapeutics. Students in our group have engaged in synthetic chemistry (organic and inorganic syntheses), physical methods (NMR, EPR, IR, CD, and UV-vis spectroscopy, mass spectrometry, and X-ray crystallography), as well as biological techniques (biological assays and mammalian cell culture/analysis).

Recent Publications     

Contents
97. Jeffrey S. Derrick, Yujeong Kim, Hyeonwoo Tak, Kiyong Park,* Jaeheung Cho,* Sun Hee Kim,* Mi Hee Lim* Dalton Trans. 2017, In Press. "Stereochemistry of Metal Tetramethylcyclam Complexes Directed by an Unexpected Anion Effect" 
96. Yonghwan Ji, Hyuck Jin Lee, Minjeong Kim, Geewoo Nam, Shin Jung C. Lee, Jaeheung Cho, Cheol-Min Park,* Mi Hee Lim* Inorg. Chem. 2017, 56, 6695-6705. "Strategic Design of 2,2-Bipyridine Derivatives to Modulate Metal–Amyloid-β Aggregation" 
94. Jeffrey S. Derrick, Jiwan Lee, Shinjung C. Lee, Yujeong Kim, Hyeonwoo Tak, Eunju Nam, Sunhee Kim,* Kiyoung Park,* Jaeheung Cho,* Mi Hee Lim* J. Am. Chem. Soc. 2017, 139, 2234-2244. “Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides” 
93. Hyuck Jin Lee, Kyle J. Korshavn, Younwoo Nam, Juhye Kang, Thomas J. Paul, Richard A. Kerr, Il Seung Youn, Mehmet Ozbil, Kwang S. Kim, Brandon T. Ruotolo, Rajeev Prabhakar,* Ayyalusamy Ramamoorthy,* Mi Hee Lim* Chem. Eur. J. 2017, 23, 2706-2715. "Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-related Pathological Features in Alzheimer's Disease" 
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Recent News

Contents
80. July 2017: Juhye and Jiyeon, Congrats for the Poster Awards in the 2017 Bioinorganic Symposium. 
79. July 2017: Our lab was highlighted by "화학세계" 
78. May 2017: Congrats, Jeff, for publishing his work in Dalton Trans. 
77. May 2017: Congrats, Yonghwan, Hyuck Jin, Geewoo, for publishing their work in Inorg. Chem.! 
76. February 2017: Congrats, Jeff, Shinjung, Eunju, Juhye, and Misun, for being selected as Spotlights and Front cover from J. Am. Chem. Soc.! 
75. January 2017: Congrats, Juhye, for her paper being selected as "Editor's Choice: Spotlights from ChemPubSoc Europe & Asian Chemical Editorial Society (ACES)"!  
74. January 2017: Congrats, Juhye, for her paper being selected as a "Hot Paper"! 
73. January 2017: Welcome, our new PhD student, Eunju! 
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