3. Research‎ > ‎

b. Highlights

  

Review Articles

  • Curr. Opin. Chem. Biol. 2017, In Press. "Impaired Metal Ion Homeostasis and Mitochondrial Dysfunction in Neurons"
  • Chem. Soc. Rev. 201746, 310-323. "Towards an Understanding of Amyloid-β Oligomers; Characterisaton, Toxicity Mechanism, and Inhibitors"
  • Acc. Chem. Res. 2014, 47, 2475-2482. "The Ongoing Search for Small Molecules to Study Metal-Associated Amyloid-β Species in Alzheimer's Disease"
  • Chem. Soc. Rev. 201443, 6672-6682"Cholesterol and Metal Ions in Alzheimer's Disease"
  • Curr. Opin. Chem. Biol. 201216, 67-73. “Metal-Associated Amyloid-β Species in Alzheimer’s Disease”
  • Chem. Soc. Rev201241, 608-621. “Misfolded Proteins in Type II Diabetes and Alzheimer’s Disease” 

Research Articles

  • J. Am. Chem. Soc. 2017139, 2234-2244. “Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides”
  • Nat. Commun. 2016, 7, 13115. "Structure-Mechanism-Based Engineering of Chemical Regulators for Distinct Pathological Factors in Alzheimer's Disease"
  • J. Am. Chem. Soc2015137, 14785-14797. "A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms"
  • Chem. Sci. 20156, 1879-1886. "A Rationally Designed Small Molecule for Identifying an In Vivo Link of Metal-Amyloid-β Complexes to the Pathogenesis of Alzheimer's Disease"
  • J. Am. Chem. Soc. 2014136, 299-310. “Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease”
  • ACS Chem. Biol. 2013, 8, 856-865. “Alzheimer's Disease: Untangling Amyloid-β, Tau, and Metals”
  • Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 3743-3748. "Insights into the Antiamyloidogenic Properties of the Green Tea Extract (−)-Epigallocatechin-3-gallate toward Metal-associated Amyloid-β Species”
  • Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 21990-21995. “Development of Small Molecules That Target Metal-Aβ Species and Regulate Metal-Induced Aβ Aggregation and Neurotoxicity”
  • J. Am. Chem. Soc. 2009, 131, 16663-16665. “Small Molecule Modulators of Copper-Induced Aβ Aggregation”