4. Publications & Patents

Publications and Patents:
 
Publications from Independent Career:

105. Jiyeon Han, Hyuck Jin Lee, Kyu Yeon Kim,Shin Jung C. Lee, Jaeheung Cho, Junghyun Chae,* Mi Hee Lim* ACS Chem. Neurosci. 2018, Accepted for Publication. "Tuning Structures and Properties for Developing Novel Chemical Tools Towards Distinct Pathogenic Elements in Alzheimer's Disease"

104. Jin Yeong Yun, Tae Geun Jo, Jiyeon Han, Hyo Jung Jang, Mi Hee Lim, Cheal Kim* Sensor Actuat B-Chem. 2018, 255, 3108-3116. "A Highly Sensitive and Selective Fluorescent Chemosensor for the Sequential Recognition of Zn2+ and S2- in Living Cells and Aqueous Media"

103. Eunju Nam, Jiyeon Han, Jong-Min Suh, Yelim Yi, Mi Hee LimCurr. Opin. Chem. Biol. 2018, 43, 8-11. "Link of Impaired Metal Ion Homeostasis to Mitochondrial Dysfunction in Neurons"

102. Michael W. Beck, Jeffrey S. Derrick, Jong-Min Suh, Mingeun Kim, Kyle J. Korshavn, Richard A. Kerr, Woo Jong Cho, Scott D. Larsen, Brandon T. Ruotolo, Ayyalusamy Ramamoorthy,* Mi Hee Lim* ChemMedChem 2017, 12, 1828-1838. Minor Structural Variations of Metal Chelators Tune Regulatory Activities towards Pathological Factors in Alzheimer’s Disease”

101. Taesu Choi, Hyuck Jin Lee, Jong Yoon Han, Mi Hee Lim,* Hugh I. Kim* J. Am. Chem. Soc. 2017, 139, 15437-15445. "Molecular Insights into Human Serum Albumin as a Receptor of Amyloid-β in the Extracellular Region "

100. Juhye Kang, Yelim Yi, Mi Hee LIm* Chemworld 2017, 8, 13-20. "Development of Small Molecules to Target Metal-Aβ in Alzheimer's Disease"

99. Tae Geun Jo, Jae Min Jung*, Jiyeon Han, Mi Hee Lim, Cheal Kim* RSC Adv. 2017, 7, 28723-28732. "A Single Fluorescent Chemosensor for Multiple Targets of Cu2+, Fe2+/3+ and Al3+ in Living Cells and a Near-Perfect Aqueous Solution"

98. Michael R. Jones, Emilie Mathieu, Christine Dyrager, Simon Faissner, Xavier Vaillancourt, Kyle J. Korshavn, Mi Hee LimAyyalusamy Ramamoorthy, V. Wee Yong, Shigeki Tsutsui, Peter K. Stys,  Tim Storr* Chem. Sci. 2017, 8, 5636-5643. "Mutli-target-Directed Phenol-Triazole Ligands as Therapeutic Agents for Alzheimer's Disease"

97. Jeffrey S. Derrick, Yujeong Kim, Hyeonwoo Tak, Kiyong Park,* Jaeheung Cho,* Sun Hee Kim,*  Mi Hee Lim* Dalton Trans. 201746, 13166-13170. "Stereochemistry of Metal Tetramethylcyclam Complexes Directed by an Unexpected Anion Effect"
 
96. Yonghwan Ji, Hyuck Jin Lee, Minjeong Kim, Geewoo Nam, Shin Jung C. Lee, Jaeheung Cho, Cheol-Min Park,* Mi Hee Lim* Inorg. Chem. 2017, 56, 6695-6705. "Strategic Design of 2,2-Bipyridine Derivatives to Modulate Metal–Amyloid-β Aggregation"

95. Myeong-Gyun Kang, Jumi Park, Gianfranco Balboni, Mi Hee Lim, Changwoo Lee, Hyun-Woo Rhee* ACS Synth. Biol. 20176, 667-677. "Genetically Encodable Bacterial Flavin Transferase for Fluorogenic Protein Modification in Mammalian Cells"

94. Jeffrey S. Derrick, Jiwan Lee, Shin Jung C. Lee, Yujeong Kim, Eunju Nam, Hyeonwoo Tak, Juhye Kang, Misun Lee, Sunhee Kim,* Kiyoung Park,* Jaeheung Cho,* Mi Hee Lim* J. Am. Chem. Soc. 2017139, 2234-2244. “Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides”
 
93. Hyuck Jin Lee, Kyle J. Korshavn, Younwoo Nam, Juhye Kang, Thomas J. Paul, Richard A. Kerr, Il Seung Youn, Mehmet Ozbil, Kwang S. Kim, Brandon T. Ruotolo, Rajeev Prabhakar,* Ayyalusamy Ramamoorthy,*  Mi Hee Lim* Chem. Eur. J. 201723, 2706-2715. "Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-related Pathological Features in Alzheimer's Disease"

92. Ha Young Jeong, Seong Youl Lee,* Jiyeon Han, Mi Hee Lim,* Cheal Kim* Tetrahedron 201773, 2690-2697. " Thiophene and Diethylaminophenol-based "Turn-on" Fluorescence Chemosensor for Detection of Al3+ and F- in a near-perfect Aqueous Solution"

91. Jae Min Jung, Jae Jun Lee, Eunju Nam, Mi Hee Lim, Cheal Kim*, Roger G. Harrison* Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. 2017178, 203-211. "A Zinc Fluorescent Sensor Used to Detect Mercury(II) and Hydrosulfide"

90. Shin Jung C. Lee, Eunju Nam, Hyuck Jin Lee, Masha G. Savelieff, Mi Hee Lim* Chem. Soc. Rev. 201746, 310-323. "Towards an Understanding of Amyloid-β Oligomers; Characterisaton, Toxicity Mechanism, and Inhibitors" 

89. Juhye Kang, Shin Jung C. Lee, Jung Seung Nam, Hyuck Jin Lee, Myeong-Gyun Kang, Kyle J. Korshavn, Hyun-Tak Kim, Jaeheung Cho, Ayyalusamy Ramamoorthy, Hyun-Woo Rhee*, Tae-Hyuk Kwon*, Mi Hee Lim* Chem. Eur. J. 201723, 1645-1653. "An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation"

88. Kyle J. Korshavn, Cristina Satriano, Yuxi Lin, Rongchun Zhang, Mark Dulchavsky, Anirban Bhunia, Magdalena lvanova, Young-Ho Lee, Carmelo La Rosa, Mi Hee Lim, Ayyalusamy Ramamoorthy* J. Biol. Chem. 2017292, 4638-4650. "Reduced Lipid Bilayer Thickness Modulates the Aggregation and Cytotoxicity of Aβ"

87. Jae Min Jung, Seong Youl Lee, Eunju Nam, Mi Hee Lim*, Cheal Kim* Sensor Actuat B-Chem. 2017, 244, 1045-1053. "A Highly Selective Turn-on Chemosensor for Zn2+ in Aqueous Media and Living Cells"

86. Tae Geun Jo, Kwon Hee Bok, Jiyeon Han, Mi Hee Lim,  Cheal Kim* Dyes Pigm. 2017, 139, 136-147. "Colorimetric Detection of Fe3+ and Fe2+ and Sequential Fluorescent Dectection of Al3+ and Pyrophosphate by an Imidazole-based Chemosensor in a near-Perfect Aqueous Solution"

85. Michael W. Beck, Jeffrey S. Derrick, Richard A. Kerr, Shin Bi Oh, Woo Jong Cho, Shin Jung C. Lee, Yonghwan Ji, Jiyeon Han, Zahra Aliakbar Tehrani, Nayoung Suh, Sujeong Kim, Scott D. Larsen, Kwang S. Kim*, Joo-Yong Lee*, Brandon T. Ruotolo*, Mi Hee Lim* Nat. Commun. 2016, 7, 13115. "Structure-Mechanism-Based Engineering of Chemical Regulators for Distinct Pathological Factors in Alzheimer's Disease"

84. Tae Geun Jo, Jae Jun Lee, Eunju Nam, Kwon Hee Bok, Mi Hee Lim,* Cheal Kim* New J. Chem. 2016, 40, 8918-8927. "A Highly Selective Fluorescent Sensor for the Detection of Al3+ and CN- in Aqueous Solution: Biological Applications and DFT Calculations" 

83. Jong-Suk Park, Eunju Nam, Hye-Kyeong Lee, Mi Hee Lim,* Hyun-Woo Rhee* ACS Chem. Biol. 201611, 2177-2185 "In Cellulo Mapping of Subcellular Localized Bilirubin"

82. Jung Seung Nam, Myeong-Gyun Kang, Juhye Kang, Sun-Young Park, Shin Jung C. Lee, Hyun-Tak Kim, Jeong Kon Seo, Oh-Hoon Kwon, Mi Hee Lim,* Hyun-Woo Rhee,* Tae-Hyuk Kwon* J. Am. Chem. Soc. 2016, 138, 10968-10977. "Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications"

81. Swapna Bera, Kyle J. Korshavn, Rajiv K. Kar, Mi Hee LimAyyalusamy Ramamooorthy, Anirban Bhunia*  Phys. Chem. Chem. Phys. (PCCP 2016, 18, 16890-16901. "Biophysical Insights into the Membrane Interaction of the Core Amyloid-Forming Aβ40 Fragment K16-K28 and its Role in the Pathogenesis of Alzheimer's Disease"

80. Shin Jung C. Lee, Tae Su Choi, Jong Wha Lee, Hyuck Jin Lee, Dong-Gi Mun, Satoko Akashi, Sang-Won Lee, Mi Hee Lim,* Hugh I. Kim* Chem. Sci. 2016, 7, 5398-5406. “Structure and Assembly Mechanism of Toxic Human Islet Amyloid Polypeptide Oligomers Associated with Copper

79. Michael R. Jones, Christine Dyrager, Marie Hoarau, Kyle J. Korshavn, Mi Hee LimAyyalusamy Ramamooorthy, Tim Storr* J. Inorg. Biochem. 2016, 158, 131-138. Multifunctional Quinoline-Triazole Derivatives as Potential Modulator for Aβ Aggregation"

78. Ye Won Choi, Jae Jun Lee, Eunju Nam, Mi Hee Lim, Cheal Kim* Tetrahedron 2016, 72, 1998-2005. "A Fluorescent Chemsensor for Al3+ Based on Julolidine and Tryptophan Moieties"

77. Jae Jun Lee, Yong Sung Kim, Eunju Nam, Sun Young Lee, Mi Hee Lim,* Cheal Kim* Dalton Trans.  2016, 45, 5700-12. "A PET-based Fluorometric Chemosensor for Determination of Mercury(II) and pH, and Hydrolysis Reaction-Based Colorimetric Detection of Hydrogen Sulfide"

76. Jeffrey S. Derrick, Richard A. Kerr, Kyle J. Torshavn, Michael J. McLane, Juhye Kang, Eunju Nam, Ayyalusamy Ramamooorthy, Brandon T. Ruotolo, Mi Hee LimInorg. Chem. 201655, 5000-5013. “The Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer's Disease"

75. Hyuck Jin Lee, Richard A. Kerr, Kyle J. KorshavnJiyeon Lee, Juhye Kang,  Ayyalusamy Ramamoorthy,* Brandon T. Ruotolo,* Mi Hee Lim* Inorg. Chem. Front. (RSC) 20163, 381- 392. "Effects of Hydroxyl Group Variations on a Flavonoid Backbone toward Modulation of Metal-Free and Metal-Induced Amyloid-β Aggregation" (Theme Issue of the 2015 Emerging Investigators by RSC ICF)  

74. Kyle J. Korshavn, Anirban Bhutia, Mi Hee Lim and Ayyalusamy Ramamoorthy* Chem. Commun. 201652, 882-885"Amyloid-β Adopts a Conserved, Partially Folded Structure upon Binding to Zwitterionic Lipid Bilayers Prior to Amyloid Formation"

73. Jeffrey S. Derrick, Richard A. Kerr, Younwoo Nam, Shin Bi Oh, Hyuck Jin Lee, Kaylin G. Earnest, Nayoung Suh, Kristy L. Peck, Mehmet Ozbil, Kyle J. Korshavn, Ayyalusamy Ramamoorthy, Rajeev Prabhakar, Edward J. Merino, Jason Shearer,* Joo-Yong Lee,* Brandon T. Ruotolo,* Mi Hee Lim* J. Am. Chem. Soc. 2015, 137, 14785-14797. "A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms"

72. Kyle J. Korshavn, Milim Jang, Yeon Ju Kwak, Akiko Kochi, Silvia Vertuani, Stefano Manfredini,* Ayyalusamy Ramamoorthy* and Mi Hee Lim* Sci. Rep. 2015, 5:17842. "Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives"

71. Mi Hee Lim* and Yi Lu* Curr. Opin. Chem. Biol. 2015, 25, vii-viii. "Editorial Overview: Bioinorganic Chemistry: Bioinorganic Catalysis for Renewable Energy"

70. Jeffrey Derrick and Mi Hee Lim* ChemBioChem 2015, 16, 887-898. "Tools of the Trade: Investigations into Design Strategies of Small Molecules to Target Components in Alzheimer's Disease"

69. Michael W. Beck, Shin Bi Oh, Richard A. Kerr, Hyuck Jin Lee, So Hee Kim, Sujeong Kim, Milim Jang, Brandon T. Ruotolo*, Joo-Yong Lee* and Mi Hee Lim* Chem. Sci. 20156, 1879-1886. "A Rationally Designed Small Molecule for Identifying an In Vivo Link of Metal-Amyloid-β Complexes to the Pathogenesis of Alzheimer's Disease"

68. Akiko Kochi, Hyuck Jin Lee, Sashiprabha M. Vithanarachchi, Vediappen Padmini, Matthew J. Allen* and Mi Hee Lim* Curr. Alzheimers Res. 2015, 12, 415-423. "Inhibitory Activity of Curcumin Derivatives Towards Metal-Free and Metal-Indiced Amyloid-β Aggregation"
 
67. Meghan R. Porter, Akiko Kochi, Jonathan A. Karty, Mi Hee Lim* and Jeffrey M. Zaleski* Chem. Sci. 2015, 6, 1018-1026. "Chelation-Induced Diradical Formation as an Approach to Modulation of the Amyloid-β Aggregation Pathway"
 
66. Alaina S. DeToma, Christine M. Dengler-Crish, Aniruddha Deb, Joseph J. Braymer, James E. Penner-Hahn, Cornelis J. van der Schyf, Mi Hee Lim* and Samuel D. Crish* BioMetals 2014, 27, 1291-1301. "Abnormal Metal Levels in the Primary Visual Pathway of the DBA/2J Mouse Model of Glaucoma"
 
65. Alaina S. DeToma, Janrthan Krishnamoorthy, Younwoo Nam, Hyuck Jin Lee, Jeffrey R. Brender, Akiko Kochi, Dongkuk Lee, Valentina Onnis, Cenzo Congiu, Stefano Manfredini, Silvia Vertuani, Gianfranco Balboni*, Ayyalusamy Ramamoorthy* and Mi Hee Lim* Chem. Sci. 2014, 5, 4851-4862. "Interaction and Reactivity of Synthetic Aminoisoflavones with Metal-Free and Metal-Associated Amyloid-β Species"
 
64. Christopher J. Chang,* Benjamin F. Cravatt,* Douglas S. Johnson* and Mi Hee Lim* Chem. Soc. Rev. 2014, 43, 6668-6671. Editorial: The Themed Issued of "Molecular Medicine and Neurodegenerative Diseases"
 
63. Masha G. Savelieff, Alaina S. DeToma, Jeffrey S. Derrick and Mi Hee Lim* Acc. Chem. Res. 2014, 47, 2475-2482. "The Ongoing Search for Small Molecules to Study Metal-Associated Amyloid-β Species in Alzheimer's Disease"
 
62. Werner J. Geldenhuys*, Akiko Kochi, Li Lin, Vijay Sutariya, Dean E. Dluzen, Cornelis J. Van der Schyf and Mi Hee Lim* ChemBioChem 2014, 15, 1591-1598. "Methyl Yellow: a Potential Drug Scaffold for Parkinson's Disease"
 
61. Hyuck Jin Lee, Younwoo Nam and Mi Hee Lim* Chemworld 2014, 54, 22-27, "알츠하이머 질병에 관련된 금속-아밀로이드 베타 펩타이드 착물의 반응성을 조절할 수 있는 화학도구 개발"
 
60. Hyuck Jin Lee, Kyle J. Korshavn, Akiko Kochi, Jeffrey S. Derrick and Mi Hee Lim* Chem. Soc. Rev. 2014, 43, 6672-6682. "Cholesterol and Metal Ions in Alzheimer's Disease"

 

59. Sanghyun Lee, Xueyun Zheng, Janarthanan Krishnamoorthy, Hyun Min Park, Jeffrey R. Brender, Masha G. Savelieff, Jin Hoon Kim, Jeffrey S. Derrick, Akiko Kochi, Hyuck Jin Lee, Cheal Kim, Ayyalusamy Ramamoorthy*, Michael T. Bowers* and Mi Hee Lim* J. Am. Chem. Soc. 2014, 136, 299-310. “Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease”

58. Masha G. Savelieff, Yuzhong Liu, Russell R. P. Senthamarai, Kyle J. Korshavn, Hyuck Jin Lee, Ayyalusamy Ramamoorthy* and Mi Hee Lim* Chem. Commun. 201450, 5301-5303“A Small Molecule that Displays Marked Reactivity with Copper- versus Zinc-Amyloid-β Implicated in Alzheimer’s Disease” (Selected in Chem. Commun. "Contributors to the Emerging Investigators Issue 2014")

57. Michael W. Beck, Amit S. Pithadia, Alaina S. DeToma, Kyle J. Korshavn and Mi Hee Lim* Chapter 10: “Ligand Design to Target and Modualte Metal-Protein Interactions in Neurodegenerative Diseases” in “Ligand Design in Medicinal Inorgnaic Chemistry” (John Wiley & Sons, LTD., Chichester, West Sussex PO19 8SQ), 2014, Chapter 10, 257-286. Note: This paper was featured in Angew. Chem. Int. Ed. 2015, 54, 2324.

56. Akiko Kochi, Todd J. Eckroat, Keith D. Green, Abdelrahman S. Mayhoub and Mi Hee Lim* Sylvie Garneau-Tsodikova* Chem. Sci. 2013, 4, 4137-4145. "A Novel Hybrid of 6-Chlorotacrine and Metal-Amyloid-β Modulator for Inhibiton of Acetylcholine and Metal-Induced Amyloid-β Aggregation"

55. Amy M. Barrios*, Seth M. Cohen* and Mi Hee Lim* ChemCommu. 2013, 49, 5910-5911, 
Editorial "Medicinal Inorganic Chemistry" on a web themed issue

54. Ayyalusamy Ramamoorthy* and Mi Hee Lim* Biophys. J. 2013, 105, 287-288, News& Notable (Commentary). “Structural Characterization and Inhibition of Toxic Amyloid-β Oligomeric Intermediates”

53. Yuzhong Liu, Akiko Kochi, Amit S. Pithadia, Sanghyun Lee, Younwoo Nam, Michael W. Beck, Xiaoming He, Dongkuk Lee and Mi Hee Lim* Inorg. Chem. 2013, 52, 8121-30. “Tuning Reactivity of Diphenylpropynone Derivatives with Metal-Associated Amyloid-β Species via Structural Modifications”

52. Molly T. Soper, Alaina S. DeToma, Suk-Joon Hyung and Mi Hee Limand Brandon T. Ruotolo* PCCP 2013, 15, 8952-8961. “Amyloid-β/Neuropeptide Interactions Assessed by Ion Mobility-Mass Spectrometry”

51. Masha G. Savelieff, Sanghyun Lee, Yuzhong Liu and Mi Hee Lim* ACS Chem. Biol. 2013, 8, 856-865. “Alzheimer's Disease: Untangling Amyloid-β, Tau, and Metals” Note: This paper was one of the top 10 most read articles from ACS Chemical Biology between April and June 2013.

50. Suk-Joon Hyung, Alaina S. DeToma, Jeffrey R. Brender, Sanghyun Lee, Subramanian Vivekanandan, Akiko Kochi, Ayyalusamy Ramamoorthy*, Brandon T. Ruotolo* and Mi Hee Lim* Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 3743-3748. "Insights into the Antiamyloidogenic Properties of the Green Tea Extract (−)-Epigallocatechin-3-gallate toward Metal-associated Amyloid-β Species”

49. Amit S. Pithadia, Akiko Kochi, Molly T. Soper, Michael W. Beck, Sanghyun Lee, Alaina S. DeToma, Brandon T. Ruotolo* and Mi Hee Lim* Inorg. Chem. 2012, 51, 12959-12967. “Reactivity of Diphenylpropynone Derivatives Toward Metal-Associated Amyloid-Species”

48. Michael R. Jones, Erin L. Service, John R. Thompson, Michael C. P. Wang, Isaac, J. Kimsey, Alaina S. DeToma, Ayyalusamy Ramamoorthy and Mi Hee Limand Tim Storr* Metallomics 2012, 4910-920.  “Dual-Function Triazole-Pyridine Derivatives as Inhibitors of Metal-Induced Amyloid-β Aggregation” 

47. Joseph J. Braymer, Kevin P. O’Neill, Jan-Uwe Rohde* and Mi Hee Lim* Angew. Chem. Int. Ed. 2012, 51, 5376-5380. “The Reaction of a High-Valent Nonheme Oxoiron(IV) Intermediate with Hydrogen Peroxide” 

46. Xiaoming He, Hyun Min Park, Suk-Joon Hyung, Alaina S. DeToma, Cheal Kim, Brandon T. Ruotolo and Mi Hee Lim* Dalton Trans. 2012, 41, 6558–6566. “Investigation of Flavonoid Compounds as Modulators for Metal-Associated Amyloid-β Species”
Note: This paper was contributed to the themed issue on Application of Inorganic Chemistry for non-Cancer Therapeutics.

45. Amit S. Pithadia and Mi Hee Lim* Curr. Opin. Chem. Biol. 2012, 16, 67-73.
“Metal-Associated Amyloid-β Species in Alzheimer’s Disease”

44. Joseph J. Braymer, Nathan M. Merrill and Mi Hee Lim* Inorg. Chim. Acta 2012, 380, 261-268. 
“Characterization of Pyridinylimine and Pyridinylmethylamine Derivatives and Their Corresponding Metal Complexes”
Note: This paper was contributed to the Special Issue on Future Young Investigators. 

43. Alaina S. DeToma,§ Samer Salemekh,§ Ayyalusamy Ramamoorthy* and Mi Hee Lim* Chem. Soc. Rev. 2012, 41, 608–621.  (§ Equally contributed this work). “Misfolded Proteins in Type II Diabetes and Alzheimer’s Disease”

42. Joseph J. Braymer, Jung-Suk Choi, Alaina S. DeToma, Chen Wang, Kisoo Nam, Jeff W. Kampf, Ayyalusamy Ramamoorthy and Mi Hee Lim* Inorg. Chem. 2011, 50, 10724-10734. “Development of Bifunctional Stilbene Derivatives for Metal-Aβ Species”

41. Jaeheung Cho, Sujin Jeon, Samuel A. Wilson, Lei V. Liu, Eun A Kang, Joseph J. Braymer and Mi Hee Lim, Britt Hedman, Keith O. Hodgson, Joan S. Valentine, Edward I. Solomon, Wonwoo Nam. Nature, 2011, 478, 502-505. “Structure and Reactivity of a Mononuclear Nonheme Iron(III)-Peroxo Complex”

40. Werner J. Geldenhuys, Kristin S. Ko, Hilary Stinnet, Cornelis J. Van der Schyf* and Mi Hee Lim* Med. Chem. Commun. 2011, 2, 1099-1103. “Identification of Small Molecule-Based Reversible Monoamine Oxidase Inhibitors to Combat Human Neurodegerative Disorders”

39. Alaina S. DeToma,§ Jung-Suk Choi,§ Joseph J. Braymer and Mi Hee Lim* ChemBioChem 2011, 12, 1198-11201 (§ Equally contributed this work). 
“Myricetin: A Naturally Occurring Regulators for Metal-Induced Amyloid-β Species and Neurotoxicity”

38. Jung-Suk Choi, Joseph J. Braymer, Se Kyung Park, Shaik Mustafa, Junghyun Chae* and Mi Hee Lim* Metallomics 2011, 3, 284-291. “Synthesis and Characterization of IMPY Derivatives that Regulate Metal-Induced Amyloid-β Aggregation” 

37. Joseph J. Braymer,§ Alaina, S. DeToma,§ Jung-Suk Choi, Kristin S. K and Mi Hee Lim* Int. J. Alzheimers Dis. 2011, 2011/623051. 
“Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-Species in Alzheimer’s Disease” (§ Equally contributed this work)

36. Jung-Suk Choi,§ Joseph J. Braymer,§ Ravi P. R. Nanga, Ayyalusamy Ramamoorthy and Mi Hee Lim* Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 21990-21995. “Development of Small Molecules That Target Metal-Aβ Species and Regulate Metal-Induced Aβ Aggregation and Neurotoxicity” (§ Equally contributed this work)

35. Sarmad S. Hindo, Allana M. Mancino, Joseph J. Braymer, Yihong Liu, Subramanian Vivekanandan, Ayyalusamy Ramamoorthy* and Mi Hee Lim* J. Am. Chem. Soc. 2009, 131, 16663–16665. “Small Molecule Modulators of Copper-Induced Aβ Aggregation”

34.  Allana M. Mancino, Sarmad S. Hindo, Akiko Kochi and Mi Hee Lim* Inorg. Chem. 2009, 48, 9596-9598. “Effects of Clioquinol on Metal-Triggered Amyloid-β Aggregation Revisited”


Publications From BS, MSc, PhD, and Postdoc.:

33. Anna J. McConnell, Mi Hee Lim, Hang Song, Eric D. Olmon, Elizabeth E. Dervan, Jacqueline K. Barton, Inorg. Chem. 2012, 51, 12511-12520. “Luminescent Properties of Ruthenium(II) Complexes with Sterically Expansive Ligands Bound to DNA Defects”

32. Mi Hee Lim, Hang Song, Eric D. Olmon, Elizabeth E. Dervan, Jacqueline K. Barton, Inorg. Chem. 2009, 48, 5392-5397. “Sensitivity of Ru(bpy)2(dppz)2+ Luminescence to DNA Defects”

31. Mi Hee Lim, Irvin H. Lau, Jacqueline K. Barton, Inorg. Chem. 2007, 46, 9528-9530. “DNA Strand Cleavage near a CC Mismatch Directed by a Metalloinsertor”

30. Mi Hee Lim* Nat. Protocols 2007, 2, 408-415. “Preparation of a Copper-Based Fluorescent Probe for Nitric Oxide and Its Use in Mammalian Cultured Cells”

29. Mi Hee Lim, Stephen J. Lippard, Acc. Chem. Res. 2007, 40, 41-51. “Metal-Based Turn-On Fluorescent Probes for Sensing Nitric Oxide”

28. Mi Hee Lim, Brian A. Wong, William H. Pitcock, Deepa Mokshagundam, Mu-Hyun Baik, Stephen J. Lippard, J. Am. Chem. Soc. 2006, 128, 14364-14373. “Direct Nitric Oxide Detection In Aqueous Solution by Copper(II) Fluorescein Complexes”

27. Mi Hee Lim, Stephen J. Lippard, Inorg. Chem. 2006, 45, 8980-8989. “Fluorescent Nitric Oxide Detection by Copper Complexes Bearing Anthracenyl and Dansyl Fluorophore Ligands”

26. Mi Hee Lim, Chaoyuan Kuang, Stephen J. Lippard, ChemBioChem 2006, 7, 1571-1576. “Nitric Oxide-Induced Fluorescence Enhancement by Displacement of Dansylated Ligands from Cobalt”

25. Mi Hee Lim, Dong Xu, Stephen J. Lippard, Nat. Chem. Biol. 2006, 2, 375-380. “Visualization of Nitric Oxide in Living Cells by a Copper-Based Fluorescent Probe”

24. Na Young Oh, Mi Sook Seo, Mi Hee Lim, Mark B. Consugar, Mi Joo Park, Jan-Uwe Rohde, Jaehong Han, Kwan Mook Kim, Jinheung Kim, Lawrence, Jr. Que, Wonwoo Nam Chem. Commun. 2005, 5644-5646. “Self-Hydroxylation of Perbenzoic Acids at a Nonheme Iron(II) Center”

23. Mi Hee Lim, Stephen J. Lippard, J. Am. Chem. Soc. 2005, 127, 12170-12171. “Copper Complexes for Fluorescence-Based NO Detection in Aqueous Solution”

22. Rhett C. Smith, Andrew G. Tennyson, Mi Hee Lim, Stephen J. Lippard, Org. Lett. 2005, 7, 3573-3575. “Conjugated Polymer-Based Fluorescence Turn-On Sensor for Nitric Oxide”

21. Scott A. Hilderbrand, Mi Hee Lim, Stephen J. Lippard, In Topics in Fluorescence Spectroscopy; C. D. Geddes, J. R. Lakowicz, Eds; Springer, 2005, Vol. 9, pp. 163-188. “Fluorescence-Based Nitric Oxide Detection”

20. Carolyn C. Woodroofe, Mi Hee Lim, Weiming Bu, Stephen J. Lippard, Tetrahedron 2005, 61, 3097-3105. “Synthesis of Isomerically Pure Carboxylate- and Sulfonate-Substituted Xanthene Fluorophores”

19. Se-Eun Park, Woon Ju Song, Yon Ok Ryu, Mi Hee Lim, Rita Song, Kwan Mook Kim, Wonwoo Nam, J. Inorg. Biochem. 2005, 99, 424-431. “Parallel Mechanistic Studies on the Counterion Effect of Manganese Salen and Porphyrin Complexes on Olefin Epoxidation by Iodosylarenes”

18. Mi Hee Lim, Stephen J. Lippard, Inorg. Chem. 2004, 43, 6366-6370. “Fluorescence-Based Nitric Oxide Detection by Ruthenium Porphyrin Fluorophore Complexes”

17. Jan-Uwe Rohde, Stephane Torelli, Xiaopeng Shan, Mi Hee Lim, Eric J. Klinker, Jozsef Kaizer, Kui Chen, Wonwoo Nam, Lawrence Que, Jr., J. Am. Chem. Soc. 2004, 126, 16750-16761. “Structural Insights into Nonheme Alkylperoxoiron(III) and Oxoiron(IV) Intermediates by X-ray Absorption Spectroscopy”

16. Scott A. Hilderbrand, Mi Hee Lim, Stephen J. Lippard, J. Am. Chem. Soc. 2004, 126, 4972-4978. “Dirhodium Tetracarboxylate Scaffolds as Reversible Fluorescence-Based Nitric Oxide Sensors”

15. Wonwoo Nam, Se-Eun Park, In Kyung Lim, Mi Hee Lim, Jongki Hong, Jinheung Kim, J. Am. Chem. Soc. 2003, 125, 14674-14675. “First Direct Evidence for Stereospecific Olefin Epoxidation and Alkane Hydroxylation by an Oxoiron(IV) Porphyrin Complex”

14. Mi Hee Lim, Jan-Uwe Rohde, Audria Stubna, Michael R. Bukowski, Miquel Costas, Raymond Y. N. Ho, Eckard Münck, Wonwoo Nam, Lawrence Que, Jr., Proc. Natl. Acad. Sci. U.S.A., 2003, 100, 3665-3670. “An FeIV=O Complex of a Tetradentate Tripodal Nonheme Ligand”

13. Jan-Uwe Rohde, Jun-Hee In, Mi Hee Lim, William W. Brennessel, Michael R. Bukowski, Audria Stubna, Eckard Münck, Wonwoo Nam, Lawrence Que, Jr., Science, 2003, 299, 1037-1039. “Crystallographic and Spectroscopic Characterization of a Nonheme Fe(IV)=O Complex”

12. Wonwoo Nam, Sun Kyung Choi, Mi Hee Lim, Jan-Uwe Rohde, Inwoo Kim, Jinheung Kim, Cheal Kim, Lawrence Que, Jr., Angew. Chem. Int. Ed. 2003, 42, 109-111. “Reversible Formation of Iodosylbenzene-Iron Porphyrin Intermediates in the Reaction of Oxoiron(IV) Porphyrin p-Cation Radicals and Iodobenzene”

11. Wonwoo Nam, Sook Won Jin, Mi Hee Lim, Ju Yeon Ryu, Cheal Kim, Inorg. Chem. 2002, 14, 3647-3652. “Anionic Ligand Effect on the Nature of Epoxidizing Intermediates in Iron Porphyrin Complex-Catalyzed Epoxidation Reactions”

10. Wonwoo Nam, Inwoo Kim, Mi Hee Lim, Hye Jin Choi, Jeseung Lee, Ho G. Jang, Chemistry Eur. J. 2002, 8, 2067-2071. “Isolation of an Oxomanganese(V) Porphyrin Intermediate in the Reaction of a Manganese(III) Porphyrin Complex and H2O2 in Aqueous Solution”

9. Youngmee Kim, Wonwoo Nam, Mi Hee Lim, Sook Won Jin, Alan J. Loungh, Sung-Jin Kim, Acta Crystallogr. 2001, C57, 556-557. “Methoxy[meso-5,10,15,20-tetrakis(2,6-diflurorophenyl)porphyrinato]iron(III), [Fe(TDFPP)(OCH3)]”

8. Mi Hee Lim, Sook Won Jin, Yoon Jung Lee, Gil-Ja Jhon, Wonwoo Nam, Cheal Kim, Bull. Kor. Chem. Soc. 2001, 22, 93-96. “Electronic Effect of Iron(III) Porphyrin Complexes on the Epoxidation of Cyclohexene: Epoxidation versus Hydroxylation”

7. Wonwoo Nam, Mi Hee Lim, So-Young Oh, Inorg. Chem. 2000, 39, 5572-5575. “Effect of Anionic Axial Ligands on the Formation of Oxoiron(IV) Porphyrin Intermediates”

6. Wonwoo Nam, Mi Hee Lim, Sun Kyung Moon, Cheal Kim, J. Am. Chem. Soc. 2000, 122, 10805-10809. “Participation of Two Distinct Hydroxylating Intermediates in Iron(III) Porphyrin Complex-Catalyzed Hydroxylation of Alkanes”

5. Wonwoo Nam, Mi Hee Lim, So-Young Oh, Jung Hwa Lee, Ha Jin Lee, Seung Kyun Woo, Cheal Kim, Woonsup Shin, Angew. Chem. Int. Ed. 2000, 39, 3646-3649. “Remarkable Anionic Axial Ligand Effects of Iron(III) Porphyrin Complexes on the Catalytic Oxygenations of Hydrocarbons by H2O2 and the Formation of Oxoiron(IV) Porphyrin Intermediates by m-Chloroperoxybenzoic Acid”

4. Wonwoo Nam, So-Young Oh, Mi Hee Lim, Mee-Hwa Choi, So-Yeop Han, Gil-Ja Jhon, Chem. Commun. 2000, 1787-1788. “Temperature Effect on the Epoxidation of Olefins by Iron(III) Porphyrin Complex and tert-Alkyl Hydroperoxides”

3. Wonwoo Nam, Mi Hee Lim, Ha Jin Lee, Cheal Kim, J. Am. Chem. Soc. 2000, 122, 6641-6647. “Evidence for the Participation of Two distinct Reactive Intermediates in Iron(III) Porphyrin Complex-Catalyzed Epoxidation Reactions”

2. Wonwoo Nam, Yeong Mee Goh, Yoon Jung Lee, Mi Hee Lim, Cheal Kim, Inorg. Chem. 1999, 38, 3238-3240. “Biomimetic Alkane Hydroxylations by an Iron(III) Porphyrin Complex with H2O2 and a High-Valent Iron(IV) Oxo Porphyrin Cation Radical Complex”

1. Mi Hee Lim, Yoon Jung Lee, Yeong Mee Goh, Wonwoo Nam, Cheal Kim, Bull. Chem. Soc. Jpn. 1999, 72, 707-713. “Hydroxylation of Aliphatic Hydrocarbons with m-Chloroperbenzoic Acid Catalyzed by Electron-Deficient Iron(III) Porphyrin Complexes”

Patents: 

5. Mi Hee Lim* US Patent Application No.: 14/967,376; Filed: 14-December-2015" (2015) "Pharmaceutical Composition for Treating or Preventing Degenerative Brain Disease Comprising Muliti-Targeting Compounds"

4. Mi Hee Lim* Korea Appl. Publ. (10-2015-0026202) (2015) “다중 타겟을 표적으로 하는 화합물을 유효성분으로 함유하는 퇴행성 뇌질환 치료 또는 예방용 약학조성물    

3. Mi Hee Lim,* Katayoun Saatchi, Urs Hafeli, Joo-Yong Lee, US Patent Application No.: 14/362,339; Filed: 02-Jun-2014 “Compositions and Methods for the Treatment and Analysis of Neurological Disorders”

2. Jacqueline K. Barton, Brian M. Zeglis, Irvin H. Lau, Jonathan R. Hart, Mi Hee Lim, U.S. Pat. Appl. Publ. 2007, US20070224612. “Compounds and Methods for Nucleic Acid Mismatch Detection” 

1. Stephen J. Lippard, Mi Hee Lim Int. Pat. Appl. Publ. 2007, WO/2007/149105 (PCT/US2006/030227). “Fluorescein Based Sensors for Tracking Nitric Oxide in Live Cells”